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ingestible · for back pain & muscle tension

Willow Bark Extract (Salix alba)

Reviewed by the Nimbera editorial team · Last updated May 2026

Chrubasik 2000 Am J Med (PMID 10936472) - randomized double-blind trial of 210 patients with chronic low back pain exacerbation; 39% of high-dose group (240 mg salicin/day) were pain-free without rescue medication in the final week versus 6% of placebo (P < 0.001); effects evident within 1 week.$12-$25 per month

How to use

Take a standardized extract providing 120-240 mg of salicin per day. Start with 120 mg and increase to 240 mg if needed after 2 weeks. Take with food to reduce stomach irritation. Allow 1-2 weeks for full effect. Brands include Solaray Willow Bark 400 mg and Nature's Answer Willow Bark. Use for acute exacerbations of up to 4-6 weeks at a time.

How it works

Salicin, willow bark's active compound, is converted in the gut and liver to saligenin and then to salicylic acid - the same end product as aspirin metabolism, but via a different pathway and more gradually. This results in COX inhibition and anti-inflammatory and analgesic effects. The slower absorption may account for willow bark's more sustained pain relief and lower gastric irritancy compared to aspirin.

Where to buy

Solaray Willow Bark 400 mg (~$12-$18 for 100 caps), Nature's Answer Willow Bark liquid extract (~$15-$22), or Herb Pharm Willow Bark (~$18-$25). Verify that the label states salicin content. Available at health food stores and online.

Typical cost: $12-$25 per month

Safety notes

IMPORTANT - do not take willow bark if you are allergic to aspirin or salicylates, as cross-reactivity is likely. Do not combine with aspirin, NSAIDs (ibuprofen, naproxen), or anticoagulants (warfarin, heparin) without medical supervision - the combination increases bleeding risk significantly. Not safe for children under 16 (Reye syndrome risk, same as aspirin). Avoid in pregnancy. May cause stomach upset; take with food. People with kidney disease, peptic ulcer, or asthma triggered by aspirin should avoid.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Chrubasik 2000 - Am J Med (PMID 10936472)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.