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ingestible · for adrenal fatigue

Rhodiola Rosea (SHR-5 Extract)

Reviewed by the Nimbera editorial team · Last updated May 2026

A randomized, double-blind, placebo-controlled trial published in Planta Medica found 576 mg SHR-5 daily significantly reduced burnout scores and blunted the cortisol awakening response compared to placebo in fatigued subjects.$15-$35 per month

How to use

Take 200-400 mg of standardized extract (3% rosavins, 1% salidroside) in the morning or early afternoon, 30 minutes before a meal. Avoid taking within 4 hours of bedtime due to mild stimulating effects.

How it works

Rosavins and salidroside upregulate heat shock proteins and inhibit cortisol-synthesizing enzymes during the stress response, while also sensitizing serotonin and dopamine receptors to improve stress resilience without sedation.

Where to buy

Nature's Way, Gaia Herbs, Herb Pharm, Nootropics Depot (look for SHR-5 standardized extract specifically).

Typical cost: $15-$35 per month

Safety notes

May cause mild agitation or insomnia if taken late in the day. Not recommended during pregnancy or breastfeeding. May interact with stimulant medications and MAOIs. Cycle use - 5 days on, 2 days off - to prevent tolerance.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

PubMed - Olsson et al. 2009

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.