ingestible · for adrenal fatigue
Phosphatidylserine
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take 300-400 mg daily in 2-3 divided doses with meals. Best taken consistently for at least 4-6 weeks to observe effects on stress reactivity.
How it works
Phosphatidylserine is a phospholipid concentrated in neuronal membranes that increases glucocorticoid receptor density in the hippocampus, enhancing cortisol negative feedback and dampening HPA axis overactivation in chronically stressed individuals.
Where to buy
NOW Foods, Jarrow Formulas, Doctor's Best, Life Extension (widely available at Costco, iHerb, Amazon).
Typical cost: $25-$50 per month
Safety notes
Generally well tolerated. May have mild blood-thinning effects - use caution with anticoagulants. Fish-derived phosphatidylserine has a stronger evidence base than soy-derived. Discontinue 2 weeks before surgery.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
PubMed - Hellhammer et al. 2014This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.