Skip to content
Back to Athlete's Foot

topical · for athlete's foot

Neem Oil

Reviewed by the Nimbera editorial team · Last updated May 2026

Natarajan et al. 2003 in vitro study (Indian Journal of Medical Microbiology, PMID 17642990) demonstrated neem (Azadirachta indica) seed extract inhibited all three tested dermatophyte species including T. rubrum and T. mentagrophytes, with an MIC of 31 micrograms/mL. Human clinical trial evidence for tinea pedis is lacking.$8-$20 per bottle

How to use

Mix 1-2 teaspoons of cold-pressed neem oil with 1 tablespoon of a carrier oil (coconut or olive). Apply to clean, dry feet and between toes twice daily. Leave on for 30 minutes then rinse or leave on overnight with cotton socks. Continue for 4 weeks.

How it works

Nimbidin, gedunin, and azadirachtin - terpenoid compounds in neem seed oil - disrupt fungal cell wall synthesis and inhibit dermatophyte growth in vitro. Neem also has anti-inflammatory and antibacterial properties that may reduce secondary bacterial colonisation in macerated toe-web spaces.

Where to buy

Health food stores, Indian grocery stores, and online (e.g., Dabolim or Organix South brands). Ensure cold-pressed, unrefined neem oil for maximum active compound content.

Typical cost: $8-$20 per bottle

Safety notes

Raw neem oil has a very strong, pungent odour. Do not ingest - neem oil is toxic internally. Avoid use during pregnancy. Patch-test before use as some individuals develop contact dermatitis. Not a substitute for proven antifungal therapy in persistent or spreading infections.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Natarajan et al. 2003 - Indian J Med Microbiol (PMID 17642990)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.