Skip to content
Back to Low Mood & Mild Depression

ingestible · for low mood & mild depression

St. John's Wort (Hypericum perforatum)

Reviewed by the Nimbera editorial team · Last updated May 2026

NCCIH reports that multiple studies and systematic reviews show St. John's Wort is more effective than placebo and as effective as standard antidepressants for mild-to-moderate depression, though evidence for severe depression is weak.$10-$25 for a 30-day supply

How to use

Take 300 mg three times daily of a standardised extract containing 0.3% hypericin, for a total of 900 mg/day. Allow 4-6 weeks for benefit. Do not combine with prescription antidepressants under any circumstances.

How it works

Hyperforin, the primary active compound, inhibits neuronal reuptake of serotonin, dopamine, norepinephrine, GABA, and glutamate simultaneously - a broader reuptake inhibition profile than most prescription antidepressants.

Where to buy

Nature's Way Perika (standardised to 5% hyperforin), Schwabe Pharma's Kira, and Solgar St. John's Wort are reputable standardised options at pharmacies, Whole Foods, and Amazon.

Typical cost: $10-$25 for a 30-day supply

Safety notes

CRITICAL: Combining St. John's Wort with SSRIs, SNRIs, tricyclic antidepressants, MAOIs, or any serotonergic drug can cause serotonin syndrome. It significantly reduces blood levels of oral contraceptives, warfarin, HIV medications, cyclosporin, and many other drugs via CYP450 induction. Can cause photosensitivity (sunburn more easily). Not for use in pregnancy or severe depression.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

NCCIH, St. John's Wort: What You Need To Know, 2024

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.