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ingestible · for low mood & mild depression

Omega-3 EPA (Fish Oil)

Reviewed by the Nimbera editorial team · Last updated May 2026

A 2019 meta-analysis by Liao et al. in Translational Psychiatry found that EPA-dominant omega-3 formulations (at least 60% EPA, up to 1 g/day) demonstrated significant clinical benefits for depression, while DHA-dominant formulations did not, identifying EPA as the likely active component.$30-$55 for a 60-day supply

How to use

Take 1-2 g/day of an EPA-dominant fish oil (formulation providing at least 60% EPA, such as 1 g EPA + 0.5 g DHA). Take with a meal containing fat to improve absorption. High-EPA products include Nordic Naturals ProEPA and Minami MorEPA.

How it works

EPA reduces neuroinflammation by competing with arachidonic acid in inflammatory eicosanoid pathways, lowers levels of pro-inflammatory cytokines implicated in depression, and may modulate serotonin and dopamine signalling in prefrontal cortical circuits.

Where to buy

Nordic Naturals ProEPA (1060 mg EPA per serving), Minami MorEPA, and Carlson Super Omega-3 are high-EPA options available at iHerb, Amazon, and health food stores.

Typical cost: $30-$55 for a 60-day supply

Safety notes

High doses above 3 g/day total omega-3 can impair blood clotting - use caution with anticoagulants or before surgery. Can cause fishy aftertaste; enteric-coated forms reduce this. Should complement, not replace, professional mental health treatment for clinical depression.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Liao et al., Efficacy of omega-3 PUFAs in depression: meta-analysis, Transl Psychiatry, 2019

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.