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ingestible · for adrenal fatigue

Magnesium Glycinate

Reviewed by the Nimbera editorial team · Last updated May 2026

A randomized controlled trial found magnesium deficiency directly elevates HPA axis set-point (raising ACTH and CRH), and 300 mg/day supplementation combined with B6 significantly reduced stress scores in severely stressed, magnesium-deficient subjects.$15-$30 per month

How to use

Take 200-400 mg of magnesium glycinate or bisglycinate in the evening before bed. The glycinate form is gentler on the digestive system than magnesium oxide and is better absorbed.

How it works

Magnesium acts as a natural NMDA receptor antagonist and suppresses CRH secretion from the hypothalamus. Deficiency - extremely common in chronically stressed adults due to urinary magnesium wasting - amplifies HPA axis reactivity and anxiety.

Where to buy

Thorne Magnesium Bisglycinate, Pure Encapsulations, Life Extension, Designs for Health (available at health food stores and Amazon).

Typical cost: $15-$30 per month

Safety notes

High doses (above 500 mg elemental) may cause loose stools - start low and increase gradually. May interact with certain antibiotics and bisphosphonates - take 2 hours apart. Not suitable for those with severe kidney disease.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

PubMed - Boyle et al. 2017

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.