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ingestible · for joint pain & arthritis

Devil's Claw (Harpagophytum procumbens)

Reviewed by the Nimbera editorial team · Last updated May 2026

A review by Brien et al. (2006) in the Journal of Alternative and Complementary Medicine examined 14 clinical trials and found that higher-quality studies suggest Devil's Claw is effective for the reduction of pain in osteoarthritis, with a minor risk profile compared to NSAIDs.$15-$30 for a 60-day supply

How to use

Take 2400-4500 mg/day of a standardised dry Devil's Claw root extract (standardised to 50-100 mg harpagoside per dose) divided into 2-3 doses with meals. Use for 8-12 weeks to assess full benefit.

How it works

The iridoid glycoside harpagoside suppresses COX-2 expression and NF-kB activation, reducing production of prostaglandins and inflammatory cytokines. It may also inhibit matrix metalloproteinases involved in cartilage breakdown.

Where to buy

Nature's Answer Devil's Claw, Solaray Devil's Claw Root, and Gaia Herbs Devil's Claw are standardised products available at natural health retailers, iHerb, and Amazon.

Typical cost: $15-$30 for a 60-day supply

Safety notes

Contraindicated in peptic ulcers and gallstones - it stimulates bile and gastric acid secretion. Should be used with caution alongside blood thinners, diabetes medications, and antiarrhythmics. Avoid in pregnancy as it may stimulate uterine contractions. Not for use with proton pump inhibitors or antacids.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Brien et al., Devil's Claw for osteoarthritis: review of efficacy and safety, J Altern Complement Med, 2006

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.