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ingestible · for headaches & migraines

Feverfew (Tanacetum parthenium)

Reviewed by the Nimbera editorial team · Last updated May 2026

A 2015 Cochrane systematic review by Wider, Pittler, and Ernst of 6 RCTs involving 561 patients found that feverfew reduced migraine frequency by approximately 0.6 attacks per month versus placebo in the most rigorous trial (n=218), though the authors rated the evidence quality as low.$10-$25 for a 60-day supply

How to use

Take 50-150 mg/day of a standardised feverfew leaf extract (standardised to at least 0.2% parthenolide content) with food. Feverfew is a preventive remedy only - it must be taken daily, not as an acute treatment, and requires 1-3 months of consistent use before benefits are apparent.

How it works

Parthenolide, the key sesquiterpene lactone, inhibits platelet aggregation and serotonin release from platelets (which contributes to migraine cascade), suppresses NF-kB inflammatory signalling, and reduces release of prostaglandins and phospholipase A2 in vascular smooth muscle.

Where to buy

Nature's Way Feverfew (standardised to 0.7% parthenolide), Solgar Feverfew Herb Extract, and Gaia Herbs Feverfew Leaf are standardised options at natural health retailers, iHerb, and Amazon.

Typical cost: $10-$25 for a 60-day supply

Safety notes

Post-feverfew syndrome: abrupt discontinuation after prolonged use can cause rebound headache, anxiety, and joint pain - taper off gradually. May interact with blood thinners and NSAIDs. Contraindicated in pregnancy as parthenolide can stimulate uterine contractions. Some individuals experience mouth ulcers from chewing fresh leaves - use supplements instead. Avoid if allergic to plants in the Asteraceae/Compositae family (ragweed, chrysanthemum, marigold).

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Wider, Pittler, Ernst, Feverfew for preventing migraine: Cochrane review, 2015

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.