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ingestible · for heartburn & acid reflux (gerd)

Melatonin

Reviewed by the Nimbera editorial team · Last updated May 2026

Kandil et al. controlled trial (n=36, 4 groups) found melatonin improved GERD symptoms including heartburn and epigastric pain, with the authors describing it as a promising therapeutic agent for GERD. Patients with GERD have lower-than-normal nocturnal melatonin levels. PMID 20082715.$8-$18 for 60-100 tablets

How to use

Take 3-6 mg melatonin 30-60 minutes before bedtime. Some GERD-specific formulations combine melatonin with B vitamins and amino acids. Take consistently every night for at least 4-8 weeks to evaluate effectiveness.

How it works

Melatonin is produced in enterochromaffin cells of the GI tract and appears to protect esophageal epithelial cells by suppressing gastric acid secretion, increasing lower esophageal sphincter pressure, and strengthening tight junctions in the esophageal barrier. GERD patients have measurably lower nocturnal melatonin levels.

Where to buy

Natrol Melatonin 3 mg (CVS, Target, Amazon); Life Extension Melatonin 6 mg (iHerb, Amazon); Integrative Therapeutics Melatonin (health food stores, Amazon).

Typical cost: $8-$18 for 60-100 tablets

Safety notes

Morning drowsiness possible, especially at higher doses - start with 0.5-1 mg. May interact with anticoagulants, immunosuppressants, and diabetes medications. Not for use in children without physician guidance. Do not use if pregnant or breastfeeding. Melatonin is not a substitute for omeprazole or other PPIs in moderate-to-severe GERD.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Kandil et al., The potential therapeutic effect of melatonin in gastro-esophageal reflux disease, BMC Gastroenterol, 2010

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.