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ingestible · for back pain & muscle tension

Devil's Claw (Harpagophytum procumbens)

Reviewed by the Nimbera editorial team · Last updated May 2026

Gagnier 2016 Spine (PMID 26630428) - Cochrane review of 14 RCTs (2,050 participants) found devil's claw standardized to 50 mg or 100 mg harpagoside per day reduced pain more than placebo in two trials (315 participants); one trial showed equivalence to 12.5 mg/day rofecoxib (Vioxx); overall evidence rated moderate quality.$15-$35 per month

How to use

Take a standardized extract providing 50-100 mg of harpagoside per day, typically 600-1,200 mg of a 9:1 concentrated root extract, divided into two doses with meals. Use for 4-8 weeks for acute flares or as ongoing daily support for chronic low back pain. Brands with documented harpagoside content include Zeller's Devil's Claw (Doloteffin) and Nature's Way Devil's Claw standardized extract.

How it works

Devil's claw root contains harpagoside, an iridoid glycoside that inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, reducing prostaglandin synthesis in a mechanism similar to NSAIDs. It also appears to suppress TNF-alpha and IL-1beta, key inflammatory cytokines involved in musculoskeletal pain sensitization.

Where to buy

Nature's Way Devil's Claw Root (standardized, ~$15-$20 for 90 caps), Gaia Herbs Devil's Claw ($25-$35), and Herb Pharm Devil's Claw liquid extract ($20-$30). Choose products that state the harpagoside content on the label. Available at health food stores, pharmacies, and online.

Typical cost: $15-$35 per month

Safety notes

Do not use if you have gastric or duodenal ulcers - devil's claw stimulates gastric acid secretion. Use with caution if taking anticoagulants (warfarin) or antiplatelet drugs, as harpagoside may potentiate bleeding risk. May interact with antiarrhythmic drugs. Avoid in pregnancy. Not recommended in people with gallstones without physician guidance. Rare gastrointestinal side effects (diarrhea, nausea) reported at higher doses.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Gagnier 2016 - Spine (PMID 26630428)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.