topical · for athlete's foot
Ajoene (Garlic Extract) Cream
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Apply a 0.4-1% ajoene cream to affected areas twice daily. Ajoene creams are not widely available as commercial products - a pharmacist can compound them, or you can use a strong garlic-in-oil preparation as a home approximation (crush 4-5 cloves in 2 tablespoons olive oil, strain, apply). Continue for at least 7-14 days.
How it works
Ajoene is a sulfur-containing organosulphide formed when allicin in garlic degrades. It inhibits lipid synthesis in the fungal cell membrane, leading to increased permeability and cell death. It shows activity against Trichophyton rubrum, T. mentagrophytes, and Microsporum canis.
Where to buy
Compounding pharmacies can prepare ajoene cream on prescription. Garlic essential oil and high-allicin garlic supplements are available in health stores as proxies. Commercial ajoene preparations are rare outside Latin America.
Typical cost: $10-$30 for compounded cream; $5-$10 for DIY garlic-oil preparation
Safety notes
Garlic compounds can cause skin irritation and burns if applied undiluted or in high concentration. Always dilute garlic oil before skin application. Avoid mucous membranes and broken skin. Strong odour may be socially limiting. Not suitable as a sole treatment for severe or spreading infections.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
Ledezma et al. 1996 - Mycoses (PMID 9009665)This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.