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Fertility & Reproductive Health

Reviewed by the Nimbera editorial team · Last updated May 2026

Natural supplements can support reproductive health by improving egg quality, sperm parameters, and hormonal balance. Evidence is strongest for women with diminished ovarian reserve or PCOS, and for men with suboptimal sperm quality. These remedies are preconception supports, not treatments for diagnosed infertility.

When to see a doctor

Infertility requires full medical evaluation - see a reproductive endocrinologist or urologist before relying on supplements alone. If you have not conceived after 12 months of trying (or 6 months if over 35), seek medical care promptly. Any supplement use during early pregnancy should be reviewed by your OB or midwife.

Natural remedies · 4

Tap any remedy for the full how-to and citation.

How we rate evidence▾

Strong - Multiple randomised controlled trials or systematic reviews with consistent positive outcomes.

Moderate - At least one RCT or several high-quality observational studies with plausible mechanisms.

Limited - Small trials, animal studies, or traditional use with limited human clinical evidence.

Sources link directly to PubMed, Cochrane Reviews, or NCCIH.

CoQ10 (Ubiquinol)

ingestible
Xu 2024 Annals of Medicine (PMID 39129455) - systematic review and meta-analysis of 6 RCTs (n=1529 women with diminished ovarian reserve undergoing IVF/ICSI); CoQ10 pretreatment significantly increased clinical pregnancy rate (OR 1.84, 95% CI 1.33-2.53, p=0.0002), number of oocytes retrieved (MD +1.30), and number of top-grade embryos, while reducing cycle cancellation rate.
$30-$60/month for 200-400 mg ubiquinol daily

Myo-Inositol (with D-Chiro-Inositol)

ingestible
Unfer 2017 Endocrine Connections (PMID 29042448) - meta-analysis of 9 RCTs (n=496 women with PCOS); myo-inositol supplementation significantly reduced fasting insulin (SMD -1.02 µU/mL, 95% CI -1.79 to -0.25, p=0.009) and HOMA-IR index (p=0.041), and raised SHBG in trials lasting 24+ weeks, indicating reduced hyperandrogenism and improved ovulatory function.
$20-$40/month for a 4 g daily dose

Zinc (Male Fertility)

ingestible
Zhao 2016 Scientific Reports (PMID 26932683) - systematic review and meta-analysis of 20 studies (n=2600 infertile cases, 867 controls); infertile men had significantly lower seminal plasma zinc (SMD -0.64, 95% CI -1.01 to -0.28); zinc supplementation significantly increased sperm motility (SMD -1.82, 95% CI -2.63 to -1.01) and percentage of normal morphology in infertile males.
$8-$20/month

Omega-3 Fatty Acids (DHA + EPA)

ingestible
Ben-Meir 2024 Heliyon (PMID 38628754) - meta-analysis; omega-3 intake significantly improved pregnancy rates and fertilization rates in women undergoing ICSI/IVF and in natural conception; noted beneficial effect on embryo quality evaluated by morphology and morphokinetic parameters, though high heterogeneity across studies limits interpretation.
$20-$45/month for a 1000-2000 mg EPA+DHA dose

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Remedy information is compiled from primary clinical sources including PubMed, the Cochrane Library, and the National Center for Complementary and Integrative Health (NCCIH). Evidence ratings reflect published human trial data at time of writing. This content is for informational purposes only and is not a substitute for professional medical advice. Read our full disclaimer.