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ingestible · for wound healing & tissue repair

Zinc (Wound Healing)

Reviewed by the Nimbera editorial team · Last updated May 2026

Arribas Lopez 2025 BMJ Nutr Prev Health (PMID 40771531) - systematic review and meta-analysis found zinc treatment associated with improved ulcer healing at final endpoint (MD 1.41, 95% CI 1.04-1.92, p=0.03); Song 2020 Nutr Clin Pract (PMID 32166790) - meta-analysis found zinc supplementation increased healing in pressure injuries (RR 1.44, 95% CI 1.01-2.06).$8-$20 for a month's supply

How to use

Take 25-50 mg of elemental zinc daily with food during the wound healing period. Zinc sulfate (220 mg = ~50 mg elemental zinc) and zinc gluconate are common forms. Limit supplementation to the acute healing period (typically 4-8 weeks) rather than ongoing use.

How it works

Zinc is required for over 300 enzymatic reactions and plays specific roles in wound healing: it is a co-factor for metalloproteinases that remodel the extracellular matrix, supports keratinocyte migration and proliferation for re-epithelialisation, and is essential for immune cell function including neutrophil and macrophage activity during the inflammatory phase of healing. Deficiency measurably impairs each phase of wound repair.

Where to buy

Available at pharmacies and health food stores as zinc sulfate, zinc gluconate, or zinc picolinate. Check that the label states the amount of elemental zinc. Zinc is also found in red meat, shellfish (especially oysters), legumes, and pumpkin seeds.

Typical cost: $8-$20 for a month's supply

Safety notes

Do not exceed 40 mg elemental zinc per day for extended periods - chronic excess intake causes copper deficiency, which paradoxically impairs wound healing and can cause anaemia. Zinc supplements reduce absorption of certain antibiotics (fluoroquinolones, tetracyclines) and should be taken at least 2 hours apart. Can interact with thiazide diuretics. Evidence for benefit is strongest in people who are zinc-deficient; supplementation in zinc-replete individuals shows smaller gains.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Arribas Lopez 2025 - BMJ Nutr Prev Health (PMID 40771531)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.