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Zinc Supplementation

Reviewed by the Nimbera editorial team · Last updated May 2026

A landmark study found that zinc supplementation in marginally zinc-deficient elderly men doubled serum testosterone from 8.3 to 16.0 nmol/L over six months.$8-$18 per month

How to use

Take 25-45 mg elemental zinc daily with food. Zinc picolinate or zinc glycinate forms are better absorbed than zinc oxide.

How it works

Zinc is an essential cofactor for the enzymes involved in testosterone biosynthesis in Leydig cells and for 5-alpha reductase activity. Deficiency directly suppresses luteinizing hormone release and reduces testicular testosterone output.

Where to buy

Pharmacies, health food stores, Amazon - zinc picolinate or zinc glycinate are preferred forms.

Typical cost: $8-$18 per month

Safety notes

Do not exceed 40 mg elemental zinc per day long-term without medical supervision - excess zinc depletes copper and can cause nausea. Take with food to reduce stomach upset. Take separately from iron supplements.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.