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ingestible · for sore throat

Zinc Lozenges

Reviewed by the Nimbera editorial team · Last updated May 2026

Mossad et al. (1996) double-blind RCT, n=100; zinc gluconate lozenges reduced sore throat duration from 3.0 days to 1.0 day vs. placebo (P < 0.001) in adults with upper respiratory infections (PMID 8678384).$8-$15 for a pack of 18-25 lozenges, typically sufficient for one illness episode.

How to use

Dissolve one zinc gluconate or zinc acetate lozenge (containing 13-23 mg ionic zinc) slowly in the mouth every 2-3 hours while awake. Begin within 24 hours of symptom onset for best effect. Do not chew - allow to dissolve fully for maximum contact with throat tissue.

How it works

Zinc ions released from lozenges during dissolution bind to and inhibit viral coat proteins, interfering with rhinovirus replication at pharyngeal mucosal surfaces. Zinc also has anti-inflammatory effects and supports epithelial barrier function in the throat lining.

Where to buy

Zinc lozenges (Zicam, Cold-EEZE, Nature's Way) at pharmacies, grocery stores, and online. Look for zinc gluconate or zinc acetate - these ionic forms have the most evidence.

Typical cost: $8-$15 for a pack of 18-25 lozenges, typically sufficient for one illness episode.

Safety notes

Do not exceed recommended daily zinc intake (40 mg/day for adults). Intranasal zinc products have been linked to permanent loss of smell - use only oral lozenges. Common side effects include nausea and unpleasant taste, especially on an empty stomach. Long-term high zinc intake can deplete copper.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Mossad SB et al., Zinc gluconate lozenges for treating the common cold: a randomized, double-blind, placebo-controlled study, Ann Intern Med, 1996

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.