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Zinc Supplementation

Reviewed by the Nimbera editorial team · Last updated May 2026

Fabbrocini G. et al. (2019) "Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence." American Journal of Clinical Dermatology, 21(3):363-377 (PMID 31745908). Reviewed 22 RCTs; zinc was found to be beneficial in 10 of 14 acne vulgaris studies, with the strongest signal for inflammatory lesions.$8-20/month

How to use

Take 30 mg elemental zinc daily with food to reduce nausea - look for zinc gluconate, zinc picolinate, or zinc bisglycinate on the label (these forms have better absorption than zinc oxide). Take at least 2 hours away from antibiotics or iron supplements. Allow 8-12 weeks for meaningful improvement.

How it works

Zinc inhibits 5-alpha-reductase (reducing DHT-driven sebum output), suppresses inflammatory cytokines, and has mild antibacterial effects against Cutibacterium acnes.

Where to buy

Pharmacies, health food stores, and online. Common brands include Thorne, NOW Foods, and Nature Made. Check the supplement facts panel for elemental zinc content, not total salt weight.

Typical cost: $8-20/month

Safety notes

Do not exceed 40 mg elemental zinc per day long-term without medical supervision - chronic high doses deplete copper and can cause anemia and immune suppression. Common side effects include nausea, vomiting, and metallic taste; take with food to minimize this. Zinc can reduce the absorption of tetracycline and fluoroquinolone antibiotics - separate doses by 2 hours. Avoid in people with zinc sensitivity.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Fabbrocini et al. 2019, Am J Clin Dermatol

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.