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topical · for minor cuts, scrapes & wounds

Zinc Oxide Barrier Paste or Cream

Reviewed by the Nimbera editorial team · Last updated May 2026

An RCT by Agren et al. (Wound Repair Regen, 2006; n=64) found topical zinc oxide reduced Staphylococcus aureus wound infection significantly (3 vs 12 antibiotic prescriptions, p=0.005) and elevated wound zinc levels, supporting its antimicrobial and tissue-repair role in open wound healing.$5-$15 per tube

How to use

Apply a thin layer of zinc oxide cream or paste (10-40% zinc oxide) to the clean, dry wound and a 1 cm border of surrounding skin after washing the area with mild soap and water. Apply 1-2 times daily or after each dressing change. For abrasions and superficial cuts, 10% cream is adequate; for moist or irritated skin around wounds, 20-40% paste provides better barrier protection. Cover lightly with a non-adherent dressing.

How it works

Zinc is an essential co-factor for over 300 enzymes involved in cellular proliferation, protein synthesis, and collagen formation. Topical zinc oxide provides a physical antimicrobial barrier, reduces wound exudate irritation to surrounding skin, and replenishes local zinc stores that are depleted during the inflammatory and proliferative wound healing phases.

Where to buy

Desitin Rapid Relief (40% zinc oxide), Calmoseptine Ointment, Dr. Smith's Diaper Rash Ointment, or pharmacy-brand zinc oxide paste - available at CVS, Walgreens, Target, and Walmart.

Typical cost: $5-$15 per tube

Safety notes

For external use only - avoid eyes and mucous membranes. Do not apply to deep puncture wounds, animal bites, or infected wounds. Some formulations contain lanolin or peanut oil - check ingredients if you have known allergies. Zinc oxide can stain clothing and fabrics white. If skin irritation, burning, or rash develops, discontinue use. Not a substitute for suturing or medical wound closure in gaping wounds.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Agren MS et al., Topical zinc oxide for acute open wounds - RCT, Wound Repair Regen, 2006

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.