ingestible · for premenstrual syndrome
Vitex (Chasteberry / Vitex agnus-castus)
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take 20-40 mg of a standardised chasteberry extract (Ze 440 or BNO 1095) once daily in the morning, consistently throughout the month - not just in the luteal phase. Allow at least 3 menstrual cycles to assess benefit.
How it works
Vitex binds to dopamine D2 receptors in the pituitary gland, suppressing prolactin secretion. Elevated prolactin is associated with breast tenderness and luteal phase deficiency; normalising it improves PMS symptom clusters.
Where to buy
Health food stores and pharmacies. Look for standardised extracts (Ze 440 or Agnucaston). Available from Vitanica, Nature's Way, and Gaia Herbs.
Typical cost: $15-$40 per month
Safety notes
Do not use during pregnancy or breastfeeding. Avoid with hormonal contraceptives or dopamine-related medications. May cause mild nausea, headache, or skin reactions. Takes 3+ months for full effect.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.