ingestible · for bone health & osteoporosis prevention
Vitamin K2 (MK-7 form)
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take 180 mcg of MK-7 (menaquinone-7) daily with a fat-containing meal as K2 is fat-soluble. MK-7 is preferred over MK-4 due to its longer half-life in the blood (3 days vs hours) and demonstrated efficacy at lower doses. Allow at least 3 months before expecting measurable changes in bone markers.
How it works
Vitamin K2 activates osteocalcin, a protein produced by osteoblasts (bone-building cells) that must be carboxylated (a K2-dependent reaction) to bind calcium and anchor it within bone mineral. Without adequate K2, osteocalcin remains undercarboxylated and unable to perform this function, leaving newly deposited bone matrix poorly mineralized. MK-7 also suppresses osteoclast-mediated bone resorption and activates matrix Gla-protein, potentially reducing vascular calcification.
Where to buy
Jarrow Formulas MK-7 (100 mcg or 180 mcg), Life Extension Super K with Advanced K2 Complex, Thorne MK-7, NOW Foods MK-7 180 mcg. Look specifically for MenaQ7 or K2VITAL branded MK-7 on the label - these are the forms used in clinical trials.
Typical cost: $15-$35/month
Safety notes
Vitamin K2 can reduce the effectiveness of warfarin (Coumadin) and other vitamin K antagonist anticoagulants - do not supplement without consulting your physician or anticoagulation clinic if you take a blood thinner. MK-7 does not significantly affect blood clotting at typical doses in people not on anticoagulants. Does not replace DEXA screening or prescribed osteoporosis treatment.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
Ma 2022 - Frontiers in Public Health (PMID 36033779)This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.