ingestible · for gout
Vitamin C Supplementation
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take 500-1,000 mg of vitamin C daily as a supplement, or increase dietary intake through citrus fruit, kiwi, and bell peppers. Discuss dose with a healthcare provider if you have kidney stones or kidney disease.
How it works
Vitamin C increases renal uric acid clearance by competing with urate at the renal tubular reabsorption transporter (URAT1), leading to greater urinary urate excretion and lower serum uric acid levels.
Where to buy
Pharmacies, supermarkets, and online. Choose ascorbic acid or calcium ascorbate forms; buffered versions are gentler on the stomach.
Typical cost: $5-$15 per month for standard 500-1,000 mg supplements.
Safety notes
Doses above 2,000 mg/day can cause gastrointestinal upset and diarrhoea. People with a history of kidney stones (especially oxalate stones) or kidney disease should consult a doctor before supplementing. Not a replacement for prescribed urate-lowering therapy.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.