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ingestible · for muscle cramps

Vitamin B Complex

Reviewed by the Nimbera editorial team · Last updated May 2026

A double-blind placebo-controlled RCT found that 3 months of vitamin B complex supplementation produced prominent remission of nocturnal leg cramps in 86% of elderly hypertensive patients versus no significant change in placebo.$10-$20 for a 60-day supply

How to use

Take one B-complex capsule daily with a meal. Look for a formula providing at least B1 (thiamine) 100 mg, B6 (pyridoxine) 50 mg, and B12 (cobalamin) 250 mcg. Allow 4-8 weeks to see full benefit.

How it works

B vitamins support peripheral nerve conduction and neuromuscular transmission. Deficiencies - common in older adults and those on diuretics or metformin - impair motor nerve function and increase susceptibility to spontaneous muscle firing.

Where to buy

Pharmacies and health food stores - brands such as Jarrow Formulas B-Right, Solgar B-Complex 100, or Nature's Way B-100

Typical cost: $10-$20 for a 60-day supply

Safety notes

High-dose B6 (above 100 mg/day long-term) can cause peripheral neuropathy - choose moderate-dose formulas. B vitamins are water-soluble and generally well tolerated at standard doses.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

PubMed - Roffe et al. 2002

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.