Skip to content
Back to Seborrheic Dermatitis

topical · for seborrheic dermatitis

Selenium Sulfide Shampoo (1-2.5%)

Reviewed by the Nimbera editorial team · Last updated May 2026

Turcu et al. 2023 multicenter observational study (n=1,407, European Journal of Dermatology, PMID 37098775) found selenium disulfide shampoo used 2-3 times per week for 4 weeks produced at least clear improvement in 89.6% of participants, with 95.6% reporting reduced itching. Mechanism and efficacy are well-established across decades of clinical use.$8-$18 for OTC; prescription cost varies

How to use

Apply selenium sulfide 1% (OTC) or 2.5% (prescription) shampoo to wet scalp. Lather and leave on for 5-10 minutes before rinsing. Use twice weekly for 2-4 weeks to clear flares, then reduce to once weekly for maintenance.

How it works

Selenium sulfide has direct cytostatic effects on scalp keratinocytes (slowing the rapid skin cell turnover that produces flaking) and disrupts Malassezia yeast cell membranes. It also reduces sebum production in hyperactive sebaceous glands.

Where to buy

1% strength available OTC at pharmacies (Selsun Blue). 2.5% strength available by prescription in most countries.

Typical cost: $8-$18 for OTC; prescription cost varies

Safety notes

Can discolor light-coloured or chemically treated hair with prolonged use - rinse thoroughly. Avoid contact with eyes and broken skin. Has a sulphurous odour. Not recommended during pregnancy at higher concentrations - consult a doctor.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Turcu et al. 2023 - Eur J Dermatol (PMID 37098775)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.