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ingestible · for men's health & prostate support

Saw Palmetto (Serenoa repens)

Reviewed by the Nimbera editorial team · Last updated May 2026

Tacklind et al. 2012 Cochrane review (PMID 23235581) - 32 RCTs (5,666 men) found saw palmetto did not significantly improve urinary symptoms vs placebo when using rigorous methodology. However, meta-analysis of high-dose hexane extracts (320 mg) showed modest improvements in IPSS score and peak urinary flow. Evidence is mixed.$12-$25/month.

How to use

Take 160 mg of standardised saw palmetto extract (hexane extract, 85-95% fatty acids and sterols) twice daily (320 mg/day total) with food. Higher-quality extracts (Permixon brand in Europe) consistently outperform generic products in trials. Allow 3-6 months to assess effect on urinary symptoms.

How it works

Saw palmetto extracts inhibit 5-alpha-reductase (the enzyme converting testosterone to DHT, which drives prostate tissue growth), have anti-inflammatory properties at the prostate level, and may reduce alpha-adrenergic receptor activity in the bladder neck (reducing outlet resistance). The hexane lipidosterolic extract is the bioactive form.

Where to buy

NOW Foods Saw Palmetto ($10-$15/90 softgels), Nature's Way Saw Palmetto ($12-$18/120 capsules), Jarrow Formulas Saw Palmetto ($15-$22/60 softgels) - available at pharmacies and health food stores.

Typical cost: $12-$25/month.

Safety notes

Generally well tolerated. May cause mild GI discomfort - take with food. Rare reports of decreased libido (5-alpha-reductase inhibition reduces DHT). May interact with anticoagulants (mild platelet effects). May reduce PSA test values, potentially masking early prostate cancer detection - inform your urologist that you are taking saw palmetto before any PSA test. Do not use saw palmetto as a substitute for medical evaluation of urinary symptoms.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Tacklind et al. 2012 - Cochrane Database (PMID 23235581)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.