ingestible · for eye health & vision support
Saffron Extract (Crocus sativus)
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take 20 mg standardised saffron extract (standardised to >3.5% safranal and >2% crocin) once daily with food. This dose matches the studied RCT protocol. Allow at least 3 months of continuous use before evaluating effect. Use as an adjunct alongside AREDS2 supplementation for AMD patients, not as a standalone replacement.
How it works
Saffron's active carotenoids crocin and crocetin cross the blood-retinal barrier and exert neuroprotective effects on photoreceptors. They upregulate trophic factors, inhibit lipid peroxidation in retinal tissue, and have demonstrated preservation of photoreceptor morphology in animal models of light-induced retinal damage. Crocetin also improves retinal blood flow by increasing oxygen diffusivity.
Where to buy
Saffrasight (the branded ingredient used in Australian clinical research) is available through eye health specialists. Healthy Origins Saffron and Life Extension Saffron are commercially available standardised extracts. Look for products standardised to safranal content. Available via iHerb and Amazon.
Typical cost: $20-$40 per month for standardised 20 mg saffron extracts
Safety notes
Saffron at supplemental doses (20-30 mg/day) is generally well tolerated. Very high doses (5+ grams of saffron spice, far above supplement amounts) can be toxic. Saffron may have mild antiplatelet and serotonergic activity - use caution if taking SSRIs or anticoagulants. Pregnant women should avoid saffron supplements as high doses have historically been associated with uterine stimulation. Evidence for AMD is promising but from smaller trials; do not use as a substitute for ophthalmologist-monitored AMD care.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.