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topical · for rosacea & facial redness

Niacinamide (Topical Vitamin B3)

Reviewed by the Nimbera editorial team · Last updated May 2026

A randomised double-blind split-face trial by Chiu et al. (J Cosmet Dermatol, 2007; n=52) found 4% topical niacinamide produced significant persistent decreases in erythema index scores at weeks 8 and 12. A pilot study by Wozniacka et al. (Clin Exp Dermatol, 2005; n=34) found topical 1-methylnicotinamide improved 76% of rosacea patients over 4 weeks.$7-$35 depending on brand and formulation

How to use

Apply a niacinamide serum or moisturiser (containing 4-10% niacinamide) to the clean, dry face twice daily, morning and night. Niacinamide layers well with other topical treatments. A 4% concentration is sufficient for skin barrier and redness benefits; higher concentrations (up to 10%) are well tolerated by most skin types. Allow 30 seconds to absorb before layering.

How it works

Niacinamide (vitamin B3) improves skin barrier function by increasing ceramide and free fatty acid production in the epidermis, reducing trans-epidermal water loss and skin sensitivity. It also inhibits inflammatory cytokine release, reduces cutaneous erythema by modulating mast cell degranulation, and decreases reactive oxygen species production.

Where to buy

The Ordinary Niacinamide 10% + Zinc 1%, Paula's Choice 10% Niacinamide Booster, CeraVe PM Facial Moisturizing Lotion (contains niacinamide), Olay Regenerist Micro-Sculpting Cream - available at ULTA, Sephora, CVS, Target, and Amazon.

Typical cost: $7-$35 depending on brand and formulation

Safety notes

Very well tolerated by most skin types, including sensitive and rosacea-prone skin. Do not combine niacinamide with high-concentration vitamin C (L-ascorbic acid) in the same routine step - use at different times of day. Some individuals report mild flushing with high concentrations (>10%) - start with 4-5% if your skin is highly reactive. Clinical evidence for rosacea specifically is limited compared to its general skin barrier benefits.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Chiu PC et al., Anti-aging effects of kinetin and niacinamide including erythema reduction, J Cosmet Dermatol, 2007

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.