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ingestible · for migraine prevention

Riboflavin (Vitamin B2)

Reviewed by the Nimbera editorial team · Last updated May 2026

A randomized controlled trial found high-dose riboflavin 400 mg/day produced a 50% or greater reduction in attack frequency in 59% of patients versus 15% in the placebo group.$10-$20 for a 3-month supply

How to use

Take 400 mg riboflavin once daily with a meal. Note that urine will turn bright yellow - this is harmless. Allow 2-3 months to see results as mitochondrial function improves gradually.

How it works

Riboflavin is a key cofactor in mitochondrial energy production. Migraine is linked to impaired mitochondrial metabolism in neurons; high-dose B2 restores mitochondrial efficiency and reduces the energetic deficit thought to trigger cortical spreading depression.

Where to buy

Pharmacies, health food stores, Amazon - sold as standalone riboflavin 400 mg or in migraine-specific B-complex formulas.

Typical cost: $10-$20 for a 3-month supply

Safety notes

Very safe and well-tolerated at 400 mg. Bright yellow-orange urine is expected and harmless. Not a substitute for acute migraine treatment. Extremely high doses over 400 mg offer no additional benefit.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

PubMed - Schoenen et al. 1998

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.