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ingestible · for sibo (small intestinal bacterial overgrowth)

Prokinetics - Ginger Root and Artichoke Leaf

Reviewed by the Nimbera editorial team · Last updated May 2026

A 2008 study in Neurogastroenterology and Motility found that impaired migrating motor complex (MMC) activity is a primary driver of SIBO recurrence, and prokinetic agents including ginger significantly accelerated gastric emptying and small intestinal transit.$15-$35/month

How to use

Take ginger root extract 1,000-2,000 mg (5% gingerols) 30-60 minutes before bed on an empty stomach to stimulate the MMC during sleep. Artichoke leaf extract 320-640 mg before dinner is another option. Use as maintenance after SIBO eradication to prevent recurrence.

How it works

The migrating motor complex - the gut's cleaning wave that sweeps bacteria from the small intestine between meals - is often impaired in SIBO. Ginger and artichoke activate motilin receptors and 5-HT4 receptors to stimulate MMC activity, helping clear bacteria before they re-colonize.

Where to buy

Ginger extract: Jarrow Formulas, NOW Foods. Artichoke extract: Thorne, Integrative Therapeutics. Available on Amazon and health food stores.

Typical cost: $15-$35/month

Safety notes

Ginger in high doses may thin the blood - caution with anticoagulants. Prokinetics should be taken only after SIBO eradication, not during active treatment. Do not use if you have gastroparesis without medical supervision.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

PubMed - Pimentel et al. 2008

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.