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ingestible · for brain fog & poor focus

Phosphatidylserine

Reviewed by the Nimbera editorial team · Last updated May 2026

A systematic review by Kato-Kataoka et al. and multiple RCTs support phosphatidylserine for improving memory, attention, and processing speed, leading the FDA to allow a qualified health claim for cognitive decline risk reduction.$25-$50/month

How to use

Take 100 mg three times daily (300 mg total) with meals. Soy-derived phosphatidylserine is the most clinically studied form. Give it at least 6 weeks to assess benefit.

How it works

Phosphatidylserine is a phospholipid that makes up a significant portion of neuronal cell membranes. It supports membrane integrity, facilitates neurotransmitter release (especially acetylcholine and dopamine), and helps regulate cortisol, which can impair memory when chronically elevated.

Where to buy

Health food stores and online retailers. Brands like Source Naturals, NOW Foods, and Life Extension offer well-formulated products.

Typical cost: $25-$50/month

Safety notes

Generally well tolerated. May cause mild insomnia or stomach upset at higher doses. Possible blood-thinning effects at high doses - consult a doctor if on anticoagulants. Choose soy-derived over bovine for safety.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

NCCIH - Phosphatidylserine

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.