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topical · for dry & flaky skin

Petroleum Jelly (Occlusive Barrier)

Reviewed by the Nimbera editorial team · Last updated May 2026

Strong evidence$3-10

How to use

Apply a thin layer of petroleum jelly to dry or cracked areas over your regular moisturizer - especially hands, elbows, heels, and lips. Use overnight with cotton gloves or socks for best results.

How it works

Creates a near-impermeable layer that prevents transepidermal water loss (TEWL). Among the most effective occlusive agents studied, reducing TEWL by up to 98%.

Where to buy

Any pharmacy or grocery store. Vaseline Original, Aquaphor (adds ceramides), or generic petroleum jelly.

Typical cost: $3-10

Safety notes

Avoid on acne-prone facial skin - highly comedogenic for some people. Do not apply to infected or open wounds.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

American Academy of Dermatology

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.