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topical · for nausea & upset stomach

Peppermint Oil Aromatherapy

Reviewed by the Nimbera editorial team · Last updated May 2026

A 2025 systematic review in Journal of Clinical Medicine found peppermint oil inhalation significantly reduced postoperative and chemotherapy-related nausea across multiple trials, but rated certainty of evidence as LOW due to blinding challenges, small sample sizes, and risk of bias.$8-$18 for a 15 ml bottle of essential oil; $4-$8 for peppermint tea

How to use

Place 1-2 drops of food-grade peppermint essential oil on a cotton ball and hold it 1-2 inches from the nose. Inhale slowly and deeply for 2-3 minutes. Alternatively, add 2-3 drops to a personal aromatherapy inhaler. Repeat as needed every 2-4 hours. Do not apply undiluted essential oil directly to the skin around the nose. Peppermint tea (1-2 cups) is a mild alternative.

How it works

Menthol, the primary active compound in peppermint oil, activates TRPM8 cold receptors in nasal and oral mucosa, which may dampen nausea signaling through olfactory-limbic pathways. Inhaled menthol may also interact with serotonin receptors involved in the nausea reflex.

Where to buy

Health food stores, pharmacies, and online. Look for 100% pure peppermint essential oil. Brands: NOW Foods, Plant Therapy, doTERRA. For internal use or tea, use food-grade or tea-bag forms only.

Typical cost: $8-$18 for a 15 ml bottle of essential oil; $4-$8 for peppermint tea

Safety notes

Essential oils are for inhalation or diluted topical use only - do not swallow undiluted essential oil. Peppermint oil can trigger or worsen acid reflux (GERD) by relaxing the lower esophageal sphincter - avoid if you have reflux. Do not use peppermint oil near the face of infants or young children - menthol can cause respiratory distress. May interact with cyclosporine by inhibiting CYP3A4 enzyme activity at high oral doses. Skin contact with undiluted oil causes irritation.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Sobieraj DM et al. Inhaling Peppermint Essential Oil as a Promising Complementary Therapy for Nausea and Vomiting. J Clin Med. 2025.

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.