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ingestible · for systemic inflammation

Omega-3 Fish Oil (EPA + DHA)

Reviewed by the Nimbera editorial team · Last updated May 2026

Calder et al. (2020) systematic review of 68 RCTs in Biomolecules found that EPA and DHA supplementation consistently and significantly reduced circulating CRP, IL-6, and TNF-alpha across diverse adult populations, with effect sizes greatest at doses of 2-4 g/day EPA+DHA (PMID 32977576).$25-50/month for a therapeutic 2-4 g EPA+DHA dose

How to use

Take 2-4 g/day of combined EPA + DHA from concentrated fish oil capsules or liquid, taken with the largest meal of the day to improve absorption and reduce fishy reflux. Standard 1,000 mg fish oil capsules contain only 300 mg EPA+DHA - check the nutrition panel for actual EPA+DHA content and choose high-concentration products. Allow 6-12 weeks for measurable CRP reduction.

How it works

EPA and DHA compete with arachidonic acid for COX and LOX enzymes, reducing synthesis of pro-inflammatory prostaglandins (PGE2) and leukotrienes (LTB4). They also serve as precursors for specialized pro-resolving mediators - resolvins, protectins, and maresins - that actively switch off the inflammatory cascade rather than simply suppressing it.

Where to buy

Nordic Naturals Ultimate Omega, Carlson Super Omega-3, and Thorne Omega-3 are well-tested concentrated options available at pharmacies, Costco, iHerb, and Amazon. Look for IFOS or NSF certification.

Typical cost: $25-50/month for a therapeutic 2-4 g EPA+DHA dose

Safety notes

Doses above 3 g/day total omega-3 may prolong bleeding time - consult a doctor if taking warfarin, aspirin, clopidogrel, or any anticoagulant, and before surgery. Fish-derived - check for fish allergy; algae-based omega-3 is a suitable vegan alternative. May have a modest blood-pressure-lowering effect. Store in the refrigerator to prevent oxidation.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Calder et al., Biomolecules 2020

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.