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ingestible · for mood & mild depression

Omega-3 EPA

Reviewed by the Nimbera editorial team · Last updated May 2026

Sublette et al. 2011 meta-analysis (J Clin Psychiatry, PMID 21939614) - EPA-dominant formulas (>60% EPA) showed significant antidepressant effects vs placebo across RCTs; DHA-dominant formulas did not. Standardised mean difference -0.446 (p = 0.003), indicating medium clinical effect size.$25-$45/month.

How to use

Take 1,000-2,000 mg/day of EPA-dominant omega-3 (at least 60% EPA content). Look for "EPA-dominant" fish oil or pure EPA products. Take with a fatty meal. Effects accumulate over 4-8 weeks.

How it works

EPA reduces neuroinflammation by competing with arachidonic acid in eicosanoid synthesis, lowering pro-inflammatory cytokines (IL-6, TNF-alpha) that are elevated in depression. EPA also modulates phospholipid composition of neuronal membranes and may enhance serotonergic neurotransmission.

Where to buy

Nordic Naturals ProEPA ($35-$45/60 softgels), Minami Nutrition MorEPA ($30-$40), WHC UnoCardio - available online and at health food stores. Choose third-party tested products.

Typical cost: $25-$45/month.

Safety notes

Mild blood-thinning effect - caution with anticoagulants (warfarin, aspirin, heparin). May interact with blood pressure medications. Choose brands third-party tested for mercury/PCBs. Not a replacement for clinical antidepressant therapy in moderate-to-severe depression.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Sublette et al. 2011 - J Clin Psychiatry (PMID 21939614)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.