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Omega-3 DHA

Reviewed by the Nimbera editorial team · Last updated May 2026

Yurko-Mauro et al. 2010 RCT (Alzheimer's & Dementia, PMID 20434961) - 485 healthy older adults with age-related cognitive decline took 900 mg/day DHA or placebo for 24 weeks; DHA group showed significantly improved learning and memory scores equivalent to reversing approximately 3 years of cognitive aging.$20-$45/month depending on brand and DHA concentration.

How to use

Take 1,000-2,000 mg/day of marine omega-3 (with at least 600-900 mg DHA) with a fatty meal for best absorption. Choose triglyceride-form fish oil or algal DHA (vegan) over ethyl ester form. Algal DHA avoids heavy metals and is equally bioavailable.

How it works

DHA is the dominant structural fatty acid in brain grey matter and neuronal membranes. It supports membrane fluidity, synaptic plasticity, neurotransmitter signalling, and anti-inflammatory resolution via specialized pro-resolving mediators. DHA deficiency correlates with increased neuroinflammation and cognitive decline.

Where to buy

Nordic Naturals Ultimate Omega ($35-$45/60 softgels), Carlson Super DHA ($25-$35/90 softgels), Thorne Omega Plus - at pharmacies, health food stores, and online.

Typical cost: $20-$45/month depending on brand and DHA concentration.

Safety notes

Fish oil can thin blood slightly - caution with anticoagulants (warfarin, heparin, aspirin). May cause fishy burps - refrigerate capsules or take enteric-coated form. High doses (>3g/day total EPA+DHA) require medical supervision. Verify brands are third-party tested for mercury and PCBs.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Yurko-Mauro et al. 2010 - Alzheimer's & Dementia (PMID 20434961)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.