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ingestible · for high cholesterol support

Omega-3 Fatty Acids (EPA + DHA)

Reviewed by the Nimbera editorial team · Last updated May 2026

Cochrane review of 86 RCTs (Abdelhamid et al. 2020, PMID 32114706) found high-certainty evidence that long-chain omega-3s reduce triglycerides by approximately 15% in a dose-dependent manner. FDA has authorized qualified health claims for EPA/DHA and reduced risk of hypertension and coronary heart disease.$15-$40 per month depending on dose and brand.

How to use

Take 1-4 g of combined EPA + DHA daily. For triglyceride reduction, higher doses (2-4 g/day) are used under medical supervision. Take with meals to improve absorption and reduce fishy burps.

How it works

EPA and DHA reduce triglyceride synthesis in the liver, increase triglyceride clearance from the bloodstream, and modestly reduce VLDL particle production. They also have anti-inflammatory effects on vessel walls.

Where to buy

Pharmacy or grocery store. Look for fish oil capsules or liquid with a combined EPA + DHA content listed on the label. Algae-based omega-3s are available for vegetarians. ConsumerLab and IFOS certification indicate purity.

Typical cost: $15-$40 per month depending on dose and brand.

Safety notes

High doses (above 3 g/day) can increase bleeding risk - discuss with a doctor if you take blood thinners (e.g., warfarin, aspirin). Fish oil can raise LDL slightly in some people even as it lowers triglycerides. May cause fishy aftertaste, loose stools, or nausea. Store in the refrigerator to prevent oxidation.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Abdelhamid et al. Cochrane Database Syst Rev 2020 - PMID 32114706

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.