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Omega-3 Fatty Acids (EPA + DHA)

Reviewed by the Nimbera editorial team · Last updated May 2026

Wang 2023 Journal of Clinical Medicine (PMID 38002640) - systematic review and meta-analysis of 19 RCTs (n=4,246) found omega-3 supplementation significantly improved dry eye symptoms, tear break-up time, Schirmer test scores, corneal fluorescein staining, and osmolarity vs placebo, with greatest benefit at high doses and longer durations.$20-$55 per month depending on dose and brand; PRN Dry Eye formula runs $55-$70/month

How to use

Take 1,000-3,000 mg combined EPA + DHA daily with food. Triglyceride-form fish oil is better absorbed than ethyl ester form. Divide into two doses to minimise fishy aftertaste. Allow 8-12 weeks before assessing benefit. For meibomian gland dysfunction-related dry eye, warm eyelid compresses used alongside omega-3 supplementation improve outcomes.

How it works

EPA and DHA incorporate into meibomian gland secretions and lacrimal gland cell membranes, modulating the production of pro-inflammatory eicosanoids. They reduce conjunctival inflammation, improve the lipid layer of the tear film (reducing evaporation), and upregulate anti-inflammatory resolvins and protectins. Meibomian gland dysfunction - the leading cause of dry eye - is particularly responsive.

Where to buy

Nordic Naturals ProOmega 2000 and Carlson Elite Omega-3 Gems are high-quality triglyceride-form options. PRN Dry Eye Omega Benefits is a dry-eye-specific pharmaceutical-grade formula used in clinical trials. Available at iHerb, Amazon, Costco, and health food stores. Look for IFOS 5-star certification for purity.

Typical cost: $20-$55 per month depending on dose and brand; PRN Dry Eye formula runs $55-$70/month

Safety notes

Omega-3s at doses above 2,000 mg/day have anticoagulant effects - use with caution if taking warfarin, clopidogrel, apixaban, rivaroxaban, aspirin, or other antiplatelet/anticoagulant medications, as bleeding risk may increase. Those with fish or shellfish allergies should use algae-derived DHA/EPA instead. Discontinue at least 1 week before elective surgery.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.