ingestible · for liver support & detox
N-Acetyl Cysteine (NAC)
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Typical oral supplement doses for liver support range from 600-1,200 mg daily, often divided into two doses taken with food to reduce gastrointestinal side effects. NAC supplements have a sulfurous odor - this is normal. Capsule forms are easier to tolerate than powder or effervescent forms.
How it works
NAC is a precursor to glutathione, the liver's primary endogenous antioxidant. Supplementing NAC replenishes glutathione stores in hepatocytes, reducing oxidative stress and supporting the liver's capacity to neutralize reactive metabolites from drugs, alcohol, and environmental toxins.
Where to buy
Health food stores, pharmacies, and online retailers. Available as capsules, tablets, and effervescent powder. Common brands include Thorne, Jarrow Formulas, and NOW Foods.
Typical cost: $10-20/month
Safety notes
Most common side effects are nausea, vomiting, and diarrhea, especially at higher doses. NAC has antiplatelet properties and may increase bleeding risk when combined with anticoagulants (warfarin, aspirin, heparin) or antiplatelet drugs - consult your doctor before combining. Combining NAC with nitroglycerin can cause severe hypotension and intolerable headaches - avoid this combination. May worsen symptoms in people with asthma. Avoid before surgery due to potential antiplatelet effects.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
Hepatology Monthly 2010This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.