ingestible · for menopause symptoms
Evening Primrose Oil
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take 500-1000 mg of evening primrose oil (standardised to 8-10% GLA - gamma-linolenic acid) twice daily with food. Capsules are the standard form. Most trials used 2-3 months of treatment. Refrigerate after opening to prevent oxidation of the fragile fatty acids.
How it works
Evening primrose oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid precursor to anti-inflammatory prostaglandins (particularly PGE1). The proposed mechanism is that GLA metabolites modulate hypothalamic thermoregulation and reduce the frequency of vasomotor events, though this mechanism remains unconfirmed in human studies.
Where to buy
Barlean's Evening Primrose Oil (Whole Foods, iHerb), Nature's Bounty Evening Primrose Oil 1000 mg (Walmart, CVS), Jarrow Formulas EPO (iHerb, Amazon).
Typical cost: $12-$25 per month
Safety notes
May increase bleeding risk - avoid if taking blood thinners (warfarin, aspirin) or two weeks before surgery. Can lower seizure threshold - avoid with epilepsy medications or in those with seizure disorders. May cause headache, nausea, or digestive upset. Safety during pregnancy is uncertain; avoid unless directed by a doctor.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.