topical · for psoriasis
Mahonia Aquifolium (Oregon Grape) Cream
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Apply a 10% Mahonia aquifolium (Oregon grape root) cream to plaques twice daily. Most clinical trials ran for 12 weeks. Avoid broken skin and mucosal surfaces.
How it works
Berberine and other isoquinoline alkaloids in Oregon grape root inhibit keratinocyte proliferation and block 5-lipoxygenase and 12-lipoxygenase - two enzymes central to the inflammatory cascade that drives psoriatic plaque formation.
Where to buy
Health food stores, naturopathic pharmacies, and online retailers selling Relieva or similar standardised 10% Oregon grape cream.
Typical cost: $15-$35 per tube
Safety notes
Avoid contact with eyes. May stain clothing and skin yellow. Not recommended during pregnancy due to berberine content. Discontinue if rash or burning worsens.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.