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ingestible · for fibromyalgia

Magnesium Malate

Reviewed by the Nimbera editorial team · Last updated May 2026

Russell et al. 1995 (PMID 8587088; J Rheumatol, 22(5):953-8) conducted a randomized double-blind placebo-controlled crossover pilot study in 24 fibromyalgia patients using a tablet combining malic acid (200 mg) and magnesium (50 mg). The blinded fixed-dose phase showed no statistically significant benefit; however the subsequent 6-month open-label dose-escalation phase produced significant reductions in pain and tenderness scores, limiting conclusions about efficacy.$15-30/month

How to use

Typical study doses used magnesium 300-450 mg combined with malic acid 1,200-2,400 mg daily, divided into 2-3 doses taken with food. Start at the lower end for 4 weeks before considering dose escalation. Tablets labeled "magnesium malate" combine both components; verify elemental magnesium content on the label.

How it works

Magnesium is a cofactor in over 300 enzymatic reactions including ATP synthesis and NMDA receptor regulation; some researchers hypothesize that intracellular magnesium deficiency contributes to muscle pain and fatigue in fibromyalgia. Malic acid is an intermediate in the citric acid cycle and may support mitochondrial energy production in muscle tissue.

Where to buy

Health food stores, pharmacies, and online retailers (Amazon, iHerb). Common brands include Doctor's Best, NOW Foods, and Source Naturals. Look for magnesium malate specifically - not magnesium oxide, which has poor absorption.

Typical cost: $15-30/month

Safety notes

Do not use if you have chronic kidney disease or impaired renal function - the kidneys cannot excrete excess magnesium safely, and hypermagnesemia can cause cardiac arrhythmia, hypotension, and respiratory depression. May cause loose stools or diarrhea at higher doses - reduce dose if this occurs. Magnesium can reduce absorption of quinolone and tetracycline antibiotics; separate doses by at least 2-4 hours. Consult your physician before use. Evidence in fibromyalgia remains limited - do not replace prescribed treatments.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Russell et al., J Rheumatol 1995

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.