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ingestible · for chronic fatigue syndrome

Magnesium Malate

Reviewed by the Nimbera editorial team · Last updated May 2026

A randomized, double-blind, placebo-controlled crossover pilot study (n=24 fibromyalgia patients) evaluated magnesium malate (as Super Malic: 200 mg malic acid + 50 mg magnesium per tablet, 3 tablets twice daily) and found no significant effect at the fixed low dose in the blinded phase; however, open-label dose escalation produced significant reductions in pain and tenderness scores (Russell et al., Journal of Rheumatology, 1995; PMID 8587088). Direct RCT evidence specifically in ME/CFS patients is lacking.$15-30/month

How to use

Take 300-400 mg of elemental magnesium as magnesium malate daily, split into two doses (morning and evening) with food to reduce gastrointestinal side effects. Start at a lower dose (150-200 mg/day) for the first 1-2 weeks and increase gradually. Take the evening dose 1-2 hours before bed as magnesium may also support sleep quality.

How it works

Malate (malic acid) is an intermediate in the Krebs energy cycle; magnesium is a cofactor for over 300 enzymatic reactions including ATP synthesis. The malate form is theorized to specifically support mitochondrial energy production in conditions involving metabolic fatigue.

Where to buy

Health food stores, pharmacies, online retailers (iHerb, Amazon, Thorne, Pure Encapsulations). Magnesium malate is a specific compound - verify the label shows "magnesium malate" not just magnesium oxide or magnesium citrate.

Typical cost: $15-30/month

Safety notes

Magnesium can cause loose stools or diarrhea, especially at doses above 350 mg/day - reduce the dose if this occurs. Do not exceed 350 mg/day of supplemental magnesium without medical supervision. Avoid if you have renal impairment or kidney disease. May interact with certain antibiotics (tetracyclines, fluoroquinolones), bisphosphonates, and diuretics - space doses at least 2 hours apart. The evidence base is from fibromyalgia studies, not ME/CFS specifically.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Russell et al., J Rheumatol 1995

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.