Skip to content
Back to Liver Support & Detox

ingestible · for liver support & detox

Milk Thistle (Silymarin)

Reviewed by the Nimbera editorial team · Last updated May 2026

A Cochrane systematic review of 13 RCTs (n=915) found no statistically significant effect on mortality or liver disease complications; some low-quality trials showed improvements in liver enzymes but these were not confirmed in high-quality trials. NCCIH notes two funded trials showed no benefit for hepatitis C or NASH.$12-$30 per month

How to use

Take 140-420 mg of standardised silymarin extract (70-80% silymarin content) daily, divided into 2-3 doses with meals. Products labelled "milk thistle extract 80% silymarin" are most consistent. Allow 8-12 weeks before assessing any effect.

How it works

Silymarin, the active flavonoid complex in milk thistle seeds, acts as an antioxidant and may inhibit toxin entry into liver cells by blocking receptor sites on the cell membrane. It also promotes protein synthesis in hepatocytes, potentially supporting cell regeneration.

Where to buy

Nature's Way Milk Thistle Standardized (Amazon, iHerb), Jarrow Formulas Milk Thistle (Whole Foods, iHerb), Thorne Siliphos (Thorne.com). Available at most health food stores.

Typical cost: $12-$30 per month

Safety notes

May cause mild digestive upset or allergic reactions, especially in people allergic to ragweed, chrysanthemums, marigolds, or daisies. May interact with medications metabolised by CYP3A4 and CYP2C9 enzymes, including statins and some antidepressants. Avoid during pregnancy. Do not use as a substitute for medical treatment of liver disease.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Rambaldi et al., Milk thistle for liver diseases, Cochrane Database Syst Rev, 2007

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.