topical · for uneven skin tone
Licorice Root Extract Serum
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Apply serum (1-2% licorice extract) to affected areas once or twice daily. Always follow with SPF 30+ during the day.
How it works
Glabridin in licorice inhibits tyrosinase, the enzyme that produces melanin. Multiple RCTs show clinical efficacy for melasma and UV-induced pigmentation.
Where to buy
Health stores, online (The Ordinary, Mesoderm RX, Eminence Organics).
Typical cost: $12-45
Safety notes
Generally well-tolerated; safe even during pregnancy. Do not combine with retinol - can be irritating.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
Systematic Review (PMC); Mesoderm RXThis information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.