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topical · for rosacea & facial redness

Licorice Root Extract (Licochalcone A)

Reviewed by the Nimbera editorial team · Last updated May 2026

A controlled clinical study of rosacea-prone patients using a skincare regimen containing licochalcone A found significantly improved skin tolerance, reduced visible redness, and improved quality of life scores.$18-$40 for targeted rosacea moisturizers containing licochalcone A

How to use

Use a moisturizer or serum containing licorice root extract (look for licochalcone A or glabridin on the ingredient list) twice daily on affected areas. Apply to clean skin before heavier creams.

How it works

Licochalcone A, derived from licorice root, inhibits 5-lipoxygenase and cyclooxygenase enzymes, blocking leukotriene and prostaglandin synthesis that drives vascular inflammation in rosacea. Its anti-inflammatory potency in erythema tests is comparable to 1% hydrocortisone acetate, without the skin-thinning risks of steroids.

Where to buy

Eucerin Redness Relief products (contain licochalcone A), La Roche-Posay Rosaliac range, Derma E Redness Relief; available at pharmacies, Ulta, and Amazon.

Typical cost: $18-$40 for targeted rosacea moisturizers containing licochalcone A

Safety notes

Well tolerated in clinical studies on sensitive and rosacea-prone skin. Avoid if you have a known allergy to licorice or related plants. Do not confuse with ingested licorice supplements, which have different safety profiles. Discontinue if irritation occurs.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

PubMed - Kolbe et al. 2006

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.