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topical · for cold sores

Lemon Balm Cream (Melissa officinalis)

Reviewed by the Nimbera editorial team · Last updated May 2026

Koytchev et al. (1999, PMID 10589440) double-blind RCT (n=66) found standardised 1% Melissa officinalis extract cream (Lo-701) produced significantly better combined symptom scores on day 2 vs placebo (4.03 vs 4.94, p<0.05), with superior healing during the period of most intensive symptoms.$10-$20 per tube (several weeks supply)

How to use

Apply a thin layer of standardised lemon balm cream (containing at least 1% Melissa officinalis extract or 70:1 dried-herb equivalent) to the affected area 4 times daily at the first sign of tingling. Continue until the sore has healed, typically 5-10 days.

How it works

Rosmarinic acid and other polyphenols in Melissa officinalis have demonstrated in-vitro activity against HSV-1 and HSV-2 by interfering with viral attachment to host-cell receptors and inhibiting viral replication at the cellular level.

Where to buy

Pharmacies and health food stores; look for products branded as Lomaherpan, EuroPharma Melissa cream, or other standardised extracts. Available in Europe more widely than North America.

Typical cost: $10-$20 per tube (several weeks supply)

Safety notes

For topical use on lip area only - avoid contact with eyes or mucous membranes inside the mouth. Discontinue if skin irritation or allergic contact dermatitis develops. Not studied for genital herpes or internal use. Lemon balm has thyroid-modulating properties when taken orally - the topical cream at these concentrations is not a systemic concern.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Koytchev R et al., Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis, Phytomedicine, 1999

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.