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ingestible · for acute bronchitis & cough

Ivy Leaf Extract (Hedera helix)

Reviewed by the Nimbera editorial team · Last updated May 2026

Schaefer et al. (2016) double-blind RCT, n=181 adults with acute cough; ivy leaf extract (EA 575) produced statistically significant and clinically relevant reductions in cough severity vs. placebo within 48 hours, sustained through 7 days post-treatment (PMID 29441845).$8-$20 for a 100 ml bottle of standardised ivy leaf syrup.

How to use

Take ivy leaf extract syrup or drops as directed on product label - typically 5-7.5 ml of standardised syrup (35 mg dry extract) 2-3 times daily for adults. Use for up to 7 days for acute cough. Children's formulations are available at lower doses.

How it works

Alpha-hederin and hederacoside C - the key saponins in ivy leaf - relax bronchial smooth muscle (bronchodilation) and thin bronchial secretions (secretolytic effect). They also activate beta-2 adrenergic receptors in airway cells, improving mucus clearance and reducing bronchospasm-driven cough.

Where to buy

Prospan and Herbion ivy leaf cough syrups are widely available at pharmacies in Europe and online internationally. In the US, look for Hedera helix extract products at health food stores.

Typical cost: $8-$20 for a 100 ml bottle of standardised ivy leaf syrup.

Safety notes

Rare allergic reactions possible, particularly in individuals allergic to plants in the Araliaceae family. Not recommended in infants under 2 without medical advice. Avoid if you have fructose intolerance (some syrups contain sorbitol). Contact a doctor if cough worsens or persists beyond 7 days.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.