ingestible · for migraine prevention
Feverfew (Tanacetum parthenium)
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take 100-150 mg of a standardized feverfew extract (0.2% parthenolide minimum) once daily with food. Must be used continuously - stopping abruptly can cause rebound headaches.
How it works
Parthenolide, the active compound in feverfew, inhibits platelet aggregation, blocks prostaglandin synthesis, and suppresses serotonin release from platelets - all mechanisms relevant to migraine initiation. It may also inhibit CGRP-mediated vasodilation.
Where to buy
Health food stores, herb shops, Amazon - look for standardized extracts labeled 0.2%+ parthenolide. MigraHerb and Nature's Way are commonly available brands.
Typical cost: $15-$25 per month for standardized extract
Safety notes
Do not use during pregnancy - may stimulate uterine contractions. Discontinue gradually, not abruptly. May cause mouth ulcers if chewing raw leaves. Mild GI upset possible. Avoid if allergic to ragweed, chrysanthemums, or related plants.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
Cochrane - Wider et al. 2015This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.