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ingestible · for headaches & migraines

Feverfew (Tanacetum parthenium)

Reviewed by the Nimbera editorial team · Last updated May 2026

Pittler & Ernst 2004 Cochrane-style review (Cephalalgia, PMID 14973986) - 6 RCTs found feverfew effective for migraine prevention versus placebo; majority of trials showed significant reductions in migraine frequency (approx. 24% reduction). Less consistent evidence for severity reduction.$10-$20/month.

How to use

Take 100-300 mg/day of a standardised feverfew extract (0.2-0.35% parthenolide) for prevention. Effects build over 4-6 weeks. Do not use for acute migraine treatment - feverfew is preventive only.

How it works

Parthenolide (the primary active compound) inhibits platelet aggregation, blocks serotonin release from platelets, and inhibits prostaglandin synthesis and NF-kB inflammatory signalling. These actions may prevent the cascade of vascular and neuroinflammatory events that initiate migraine attacks.

Where to buy

Nature's Way Feverfew ($10-$15/100 capsules), Herb Pharm Feverfew liquid extract ($15-$20), Frontier Co-op feverfew leaf - available at health food stores and online.

Typical cost: $10-$20/month.

Safety notes

Do not use during pregnancy (uterine-stimulating effects of parthenolide). Avoid if allergic to plants in the Asteraceae family (ragweed, chrysanthemum, marigold). May interact with anticoagulants (warfarin, aspirin) - monitor INR. Post-feverfew syndrome: abrupt discontinuation after prolonged use can trigger rebound headaches, anxiety, and muscle stiffness - taper gradually.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Pittler & Ernst 2004 - Cephalalgia (PMID 14973986)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.