ingestible · for low energy & fatigue
Rhodiola Rosea
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take 200-400 mg of a standardized extract (3% rosavins, 1% salidroside) once daily, 30 minutes before breakfast on an empty stomach. Use for up to 12 weeks. Start at the lower end and assess tolerance after 2 weeks.
How it works
Rhodiola is classified as an adaptogen - it modulates the hypothalamic-pituitary-adrenal axis and influences cortisol secretion. Salidroside and rosavins are thought to reduce oxidative stress and support mitochondrial energy production. A systematic review in PMC (PMC3541197) found 3 of 5 RCTs demonstrated reduction in mental fatigue and 2 of 6 showed improvement in physical fatigue.
Where to buy
Health food stores, pharmacies, Amazon. Look for standardized extracts specifying 3% rosavins and 1% salidroside.
Typical cost: $15-35
Safety notes
Possibly safe for up to 12 weeks; safety beyond that is unknown. May cause dizziness, headache, insomnia, dry mouth, or excessive salivation. A documented interaction with losartan (blood pressure medication) has been reported by NCCIH. Avoid in pregnancy and breastfeeding. Do not combine with stimulants or medications metabolized by CYP enzymes without medical guidance.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
PMC Systematic Review (2012)This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.