ingestible · for low energy & fatigue
Cordyceps Mushroom
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take 1000-3000 mg of Cordyceps sinensis (Cs-4 fermented extract) or Cordyceps militaris powder daily in 2-3 divided doses with food. Allow 6-12 weeks of consistent use before assessing effect on energy and exercise tolerance.
How it works
Cordyceps contains adenosine and cordycepin, which are structurally similar to ATP precursors. A double-blind placebo-controlled trial (PMC3110835) found 333 mg taken three times daily for 12 weeks increased the metabolic threshold by 10.5% and ventilatory threshold by 8.5% in healthy older subjects, indicating improved oxygen utilization and delayed fatigue onset during exertion.
Where to buy
Health food stores, specialty supplement retailers, Amazon. Look for Cs-4 standardized fermentation products or full-spectrum Cordyceps militaris fruiting body powder.
Typical cost: $20-45
Safety notes
Generally well tolerated in studies up to 12 weeks with no reported adverse events (PMC3110835). May interact with immunosuppressant medications due to immune-modulating properties. Use caution if taking blood-thinning medications (warfarin, aspirin) or diabetes medications as Cordyceps may affect blood glucose and clotting. Avoid if allergic to molds or fungi.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
PMC Double-Blind RCT - Cs-4 (2010)This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.